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KMID : 0379119820100040147
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Korean Journal of Mycology
1982 Volume.10 No. 4 p.147 ~ p.154
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Studies on Constituents of Higher Fungi of Korea (33)
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Abstract
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To find antitumor components with low toxicity from natural resources, antitumor test of the water extract of the carpophores of Trumetes sanguinea (L. ex Fr.)Lloyd. was undertaken. The carpophores of this fungus were collected in Gyeong Gi Province and extracted with hot water. The extract was purified by dialyzing through Visking tube and a protein-bound polysaccharide fraction was obtained. The fraction was tested for antitumor activity against sarcoma 180 implanted in mice. The tumor inhibition ratio of the fraction against the tumor was 72.4% at the dose of 10㎎/㎏/day for the period of ten days. The tumor in one of the eight mice was completely regressed. The antitumor components were found to be a polysaccharide and a protein. The hydrolysis of the polysaccharide moiety yielded three monosaccharides, and from the hydrolysate of the protein moiety 13 amino acids were identified.
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